In FLAIR, people who were treatment-naive were started on abacavir/dolutegravir/lamivudine (Triumeq) and, if they achieved viral suppression at 20 weeks, were randomized to either stay on this oral regimen or add oral CAB and RPV (to demonstrate … A clinical trial to evaluate long-acting antiretroviral therapy (ART) for maintaining HIV suppression in people for whom adhering to conventional daily oral ART has been a challenge has begun at research sites across the United States. J Control Release. Published on Nov 22, 2019 The session outlines a study that evaluates Long Acting Injectable Antiretroviral Therapy (LA ART) as a solution to … COVID-19 is an emerging, rapidly evolving situation. People who received a combination of two long-acting injectable antiretrovirals once a month expressed a high level of satisfaction with the regimen and almost all said they preferred it to their previous oral therapy, according to two studies presented yesterday at the 10th International AIDS Society Conference on HIV Science (IAS 2019) in Mexico City. Weight gain following the initiation of antiretroviral therapy (ART) has been reported across multiple settings and study populations. “ We found that long-acting injectable antiretroviral therapy was a compelling option among the women we interviewed.” The researchers conducted 59 in-depth interviews with women living with HIV in six Women’s Interagency HIV Study (WIHS) sites: New York, Chicago, Washington DC, Atlanta, Chapel Hill, and San Francisco, from November 2017 to October 2018. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. CROI 2016: Advances in Antiretroviral Therapy. Epub 2020 Jun 15. Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery, Nature Communications (2019). Test-and-treat and rapid-ART-start strategies show promise in advancing progress toward the HIV care cascade 90-90-90 Joint United Nations Programme on HIV/AIDS/World Health Organization targets. The ATLAS-2M study examined reducing the frequency of dosing from 4-weekly to 8-weekly, the findings of which are reported by Edgar Overton and colleagues in . Cabenuva, pending FDA approval, stands to impact HIV treatment in the U.S. Cabenuva would be the first injectable antiretroviral. The compound also exhibits activity against HIV-2. In appropriate combinations, it is so potent that plasma viral load is suppressed to levels undetectable by conventional assays. Shrestha R, DiDomizio EE, Kim RS, Altice FL, Wickersham JA, Copenhaver MM. Clipboard, Search History, and several other advanced features are temporarily unavailable. Likert scores of long-acting injectable antiretroviral therapy acceptability by proposed injection-site reaction duration. CROI 2014: Advances in antiretroviral therapy. Olender S, Wilkin TJ, Taylor BS, Hammer SM. - New Data from International HIV/AIDS Society 2017. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. First long-acting injectable antiretroviral therapy for HIV recommended for approval EMA has recommended the granting of marketing authorisations for two new antiretroviral (ARV) medicines, Rekambys (rilpivirine) and Vocabria injection (cabotegravir), to be used together for the treatment of patients with human immunodeficiency virus type 1 (HIV-1) infection. CROI 2016: Advances in Antiretroviral Therapy. 2019 Oct;311-312:201-211. doi: 10.1016/j.jconrel.2019.09.001. NLM Maturation inhibitor. CROI 2018: Advances in Antiretroviral Therapy. With long-acting injectable antiretroviral therapy likely to be a treatment option for people living with HIV (PLWH), it is critical to assess its acceptability among potential end-users. | This strategy — two injections every 4 or 8 weeks — obviates the need to take antiretroviral therapy daily. Based on the results of the phase 3 efficacy studies called ATLAS and FLAIR, we know that injectable CAB/RPV is safe, well-tolerated, and (among those who chose to participate in the studies), highly popular. Kevadiya BD, Ottemann B, Mukadam IZ, Castellanos L, Sikora K, Hilaire JR, Machhi J, Herskovitz J, Soni D, Hasan M, Zhang W, Anandakumar S, Garrison J, McMillan J, Edagwa B, Mosley RL, Vachet RW, Gendelman HE. Marketing Authorisation is based on the pivotal phase III ATLAS (Antiretroviral Therapy as Long-Acting Suppression), FLAIR (First Long-Acting Injectable Regimen) and ATLAS-2M studies, which included more than 1,200 participants from 16 countries. Advances and challenges in antiretroviral therapy for acquired immunodeficiency syndrome. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. | Using longitudinal data from the Women’s Interagency HIV Study (WIHS) … Ready for HIV Dual Therapy? July 30, 2019. Would you like email updates of new search results? They had been on antiretroviral therapy for a median of four years, all had viral suppression and the median CD4 count was 653 cells/mm3. To date, women have been less represented than men in LA ART research. Chin Med J (Engl). Test-and-treat and rapid-ART-start strategies show promise in advancing progress toward the HIV care cascade 90-90-90 Joint United Nations Programme on HIV/AIDS/World Health Organization targets. Read on to learn more about the new drug and what to consider ahead of its potential arrival in early 2021. Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues. Two clinical trials of long-acting injectable cabotegravir and rilpivirine showed promising safety, efficacy, and tolerability as maintenance ART. New findings were presented on maternal and fetal health outcomes in women of reproductive potential, drug-drug interactions between hormonal contraception and ART, and further exploration of the association between InSTIs and birth defects. The association of NRTIs with short- and long-term side effects such as nausea, diarrhea, and lipodystrophy and the emergence of virus resistance have led to the search for NRTI-sparing regimens [ 3 , 4 ]. Long-acting (LA) injectable antiretroviral therapy (ART) has been found non-inferior to daily oral ART in Phase 3 trials. Author information: … 2020 Oct;117:108058. doi: 10.1016/j.jsat.2020.108058. EMA has recommended the granting of marketing authorisationsfor two new antiretroviral (ARV) medicines, Rekambys (rilpivirine) and Vocabria injection (cabotegravir), to be used together for the treatment of patients with human immunodeficiency virus type 1 (HIV-1) infection. Carlos del Rio, MD reviewing N Engl J Med 2019 Jul 24 Venter WDF et al. Top Antivir Med. Long-acting injectable antiretroviral therapy (LA ART) may be an alternative for people living with HIV (PLHIV) with adherence challenges or who prefer not to take pills. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. Among a list of presented options for primary preferred distribution venue for an injectable antiretroviral, a clear majority selected the clinician’s office (115, 57%) as their preferred venue. NIH The first long-acting injectable treatments for HIV were recommended for marketing approval on October 16 by the European Medicines Agency (EMA). National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Hilaire JR, Bade AN, Sillman B, Gautam N, Herskovitz J, Dyavar Shetty BL, Wojtkiewicz MS, Szlachetka A, Lamberty BG, Sravanam S, Fox HS, Alnouti Y, Dash PK, McMillan JM, Edagwa BJ, Gendelman HE. Long-acting injectable antiretroviral therapy (ART) offers the convenience of reduced dosing frequency and, for the combination of the long-acting rilpivirine and cabotegravir, provides an additional two-drug ART option. Olender S, Wilkin TJ, Taylor BS, Hammer SM. Epub 2020 Jun 15. eCollection 2020. DeJesus and col-leagues presented data from a phase The study, called Long-Acting Therapy to Improve Treatment Success in Daily Life, or LATITUDE, will help determine whether a combination of two experimental injectable … Epidemiologic data were reported on the prevalence, impact, regional variation, and changes over time of resistance-associated mutations. A third were women, two thirds were white, about a quarter were black and the median age was 42 years. The … Top Antivir Med. 2019 Oct 26. doi: 10.1007/s10461-019-02701-7. | Theranostics. At baseline, half were taking NNRTI-based regimens, a third were taking integrase inhibitors and 17% were o… NLM The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). Top Antivir Med. These delivery systems may give patients the ability to administer daily medication less frequently and allow in-clinic administration for those who have not disclosed their status and do not want to bring medication bottles home. [Epub ahead of print] A Conjoint Analysis of the Acceptability of Targeted Long-Acting Injectable Antiretroviral Therapy Among Persons Living with HIV in the U.S. Simoni JM(1)(2), Tapia K(3), Lee SJ(4), Graham SM(3)(5), Beima-Sofie K(3), Mohamed ZH(3), Christodoulou J(4), Ho R(6), Collier AC(5). In vitro studies were presented that identified and evaluated the effect of resistance-associated mutations on ART susceptibility and elucidated mechanisms of resistance. J Control Release. Two clinical trials of long-acting injectable cabotegravir and rilpivirine showed promising safety, efficacy, and tolerability as maintenance ART. Kevadiya BD, Ottemann B, Mukadam IZ, Castellanos L, Sikora K, Hilaire JR, Machhi J, Herskovitz J, Soni D, Hasan M, Zhang W, Anandakumar S, Garrison J, McMillan J, Edagwa B, Mosley RL, Vachet RW, Gendelman HE. and, for the combination of the long-acting rilpivirine and cabotegravir, provides an additional two-drug ART option. 2020 Oct;117:108058. doi: 10.1016/j.jsat.2020.108058. 2012 Jun-Jul;20(2):61-86. The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). Long-acting injectable antiretroviral therapy (ART) offers the convenience of reduced dosing frequency . Whilst ART does not cure HIV and AIDS, and should therefore be taken for life, it dramatically reduces mortality and morbidity if used appropriately. Epub 2019 Sep 3. This site needs JavaScript to work properly. 2016 May-Jun;24(1):59-81. However, late diagnosis and mortality after ART initiation remain high, even in the context of HIV service scale-up, and mortality from unintentional opioid overdose in people living with HIV in the United States is on the rise. Awareness about and willingness to use long-acting injectable pre-exposure prophylaxis (LAI-PrEP) among people who use drugs. AIDS Behav. EDURANT® (rilpivirine) is a once daily non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of human immunodeficiency virus (HIV-1) infection in combination with other antiretroviral agents in antiretroviral treatment-naïve patients 12 years of age and older and weighing at least 35-kg with a viral load ≤ 100,000 HIV RNA copies/mL. 2016 May-Jun;24(1):59-81. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. N Engl J Med 2019 Jul 24 Havlir DV and Doherty MC. Decreasing regional and national rates of resistance may be a benefit of increasing use of integrase strand transfer inhibitors (InSTIs). Nucleoside reverse transcriptase inhibitors (NRTIs) are important components of antiretroviral therapy (ART) when combined with other medications [1, 2]. New findings were presented on maternal and fetal health outcomes in women of reproductive potential, drug-drug interactions between hormonal contraception and ART, and further exploration of the association between InSTIs and birth defects. CROI 2018: Advances in Antiretroviral Therapy. The global ATLAS (Antiretroviral Therapy as Long-Acting Suppression) and FLAIR (First Long-Acting Injectable Regimen) pivotal phase 3 studies included more than 1,100 patients from 16 countries and concluded that the combination of cabotegravir and rilpivirine, injected monthly, was as effective as a daily, oral, three-drug regimen in maintaining viral suppression throughout the 48-week study period. 2020 Dec 5;133(23):2775-2777. doi: 10.1097/CM9.0000000000001226. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. | More information: S. Rahima Benhabbour et al. 2020 Dec 5;133(23):2775-2777. doi: 10.1097/CM9.0000000000001226. Using in-depth interviews, this study sought to understand the experiences of PLHIV (n = 53) participating in Phase 3 LA ART trials in the United States and Spain. Creation of a long-acting rilpivirine prodrug nanoformulation. Antiretroviral Therapy in 2019: Which Is the Best Regimen for the Global Roll-Out? COVID-19 is an emerging, rapidly evolving situation. Advances and challenges in antiretroviral therapy for acquired immunodeficiency syndrome. In vitro studies were presented that identified and evaluated the effect of resistance-associated mutations on ART susceptibility and elucidated mechanisms of resistance. | USA.gov. Based on formative qualitative work and our own ongoing development of targeted long-acting products in nanosusp … The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). The data supporting a regimen consisting of injectable CAB/RPV were presented at CROI 2019 in the form of a pair of open-label trials named FLAIR and ATLAS. - New Data from International HIV/AIDS Society 2017. HHS Please enable it to take advantage of the complete set of features! Two clinical trials of long-acting injectable cabotegravir and rilpivirine showed promising safety, efficacy, and tolerability as maintenance ART. The ATLAS trial, presented by Swindells, included 616 treatment-experienced patients. 2019 Oct;311-312:201-211. doi: 10.1016/j.jconrel.2019.09.001. More information: Morgan M. Philbin et al, A Qualitative Exploration of Women's Interest in Long-Acting Injectable Antiretroviral Therapy Across … 2012 Jun-Jul;20(2):61-86. Would you like email updates of new search results? Top Antivir Med. HHS This has led to the concept of “HAART”, which literally means using very … Antiretroviral therapy interrupts crucial steps of the HIV life cycle. However, late diagnosis and mortality after ART initiation remain high, even in the context of HIV service scale-up, and mortality from unintentional opioid overdose in people living with HIV in the United States is on the rise. Epidemiologic data were reported on the prevalence, impact, regional variation, and changes over time of resistance-associated mutations. eCollection 2020. Taylor BS, Olender SA, Tieu HV, Wilkin TJ. Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues. 2020 Jan 1;10(2):630-656. doi: 10.7150/thno.39847. Hilaire JR, Bade AN, Sillman B, Gautam N, Herskovitz J, Dyavar Shetty BL, Wojtkiewicz MS, Szlachetka A, Lamberty BG, Sravanam S, Fox HS, Alnouti Y, Dash PK, McMillan JM, Edagwa BJ, Gendelman HE. 2020 Jan 1;10(2):630-656. doi: 10.7150/thno.39847. antiretroviral therapy (ART) has revolutionized the care and management of HIV and AIDS and has transformed the disease from being life-threatening infection into a chronic and manageable condition. Ready for HIV Dual Therapy? 4,5,6 Cabotegravir and rilpivirine are co-administered as two intramuscular (IM) injections in the buttocks by a Healthcare Professional at the … Chin Med J (Engl). | NIH Creation of a long-acting rilpivirine prodrug nanoformulation. Shrestha R, DiDomizio EE, Kim RS, Altice FL, Wickersham JA, Copenhaver MM. J Subst Abuse Treat. N Engl J Med 2019 Jul 24. Please enable it to take advantage of the complete set of features! Marketing Authorisation is based on the pivotal phase III ATLAS (Antiretroviral Therapy as Long-Acting Suppression), FLAIR (First Long-Acting Injectable Regimen) and ATLAS-2M studies, which included more than 1,200 participants from 16 countries. Emerging alternative antiretroviral (ARV) delivery systems for HIV treatment and prevention include injectables, topicals, and implants. USA.gov. Taylor BS, Olender SA, Tieu HV, Wilkin TJ. Epub 2019 Sep 3. CROI 2019: Antiretroviral Therapy Volume 27 Issue 1 April 2019 against a broad range of HIV-1 resistant to other ART classes including those with Gag polymorphisms conferring resistance to maturation inhibitors. Awareness about and willingness to use long-acting injectable pre-exposure prophylaxis (LAI-PrEP) among people who use drugs. LA ART may address key barriers to oral ART adherence and be preferable to daily pills for some people living with HIV. Long-acting injectable rilpivirine is not approved by … J Subst Abuse Treat. Theranostics. Test-and-treat … Clipboard, Search History, and several other advanced features are temporarily unavailable. 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